Article
Heart regeneration in zebrafish.
Science (New York, N.Y.) - 13 Dec 2002
Poss Kenneth D, Wilson Lindsay G, Keating Mark T
Abstract excerpt
Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection. Regeneration occurs through robust proliferation of cardiomyocytes localized at the leading epicardial edge of the new myocardium. The hearts of zebrafish with mutations in the Mps1...
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