Article

High-sensitivity Approach for Detection of Tert Promoter Variants in Shh-activated Pediatric Medulloblastomas

2026-01-09

Abstract excerpt

<title>Abstract</title> <p> <italic>TERT</italic> promoter ( <italic>TERT</italic> p) hotspot variants − 124C > T (C228T) and − 146C > T (C250T) are recurrent in various central nervous system tumors and serve as established prognostic markers in many cases. Among medulloblastoma molecular subgroups, <italic>TERT</italic> p variants are most frequently observed in adult SHH-activated (Sonic Hedgehog) medull...

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Literature Corpus work: b622d88a-06f9-519b-81a7-f423a4a7c586
DOI: 10.21203/rs.3.rs-7527596/v1

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