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Article

Clinical and mutational profiles of adult medulloblastoma groups.

Acta neuropathologica communications - 10 Nov 2020

Wong Gabriel Chun-Hei, Li Kay Ka-Wai, Wang Wei-Wei, Liu Anthony Pak-Yin, Huang Queenie Junqi, Chan Aden Ka-Yin, Poon Manix Fung-Man, Chung Nellie Yuk-Fei, Wong Queenie Hoi-Wing, Chen Hong, Chan Danny Tat Ming, Liu Xian-Zhi, Mao Ying, Zhang Zhen-Yu, Shi Zhi-Feng, Ng Ho-Keung

Abstract excerpt

Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We performed molecular grouping, targeted sequencing, and TERT promoter Sanger sequencing on a cohort of 99 adult medulloblastomas. SHH made up 50% of the cohort, whereas Group 3 (13%) was present in comparable proportion to WNT (19%) and Group 4 (18%). In contrast to paediatric medulloblastomas, molecular groups had no...

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Identifiers

PMID: 33172502
DOI: 10.1186/s40478-020-01066-6
PMCID: PMC7656770

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