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Article

Rapid diagnosis of medulloblastoma molecular subgroups.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2011

Schwalbe Ed C, Lindsey Janet C, Straughton Debbie, Hogg Twala L, Cole Michael, Megahed Hisham, Ryan Sarra L, Lusher Meryl E, Taylor Michael D, Gilbertson Richard J, Ellison David W, Bailey Simon, Clifford Steven C

Abstract excerpt

PURPOSE: Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management. EXPERIMENTAL DESIGN: Minimal mRNA expression signatures diagnostic for the Wnt/Wingless (WNT) and Sonic Hedgehog (SHH) subgroups were developed, validated, and used to assign subgroup affiliation in 173 tumors from four independent cohorts, alongside a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21325292
DOI: 10.1158/1078-0432.CCR-10-2210
PMCID: PMC3071325

Genes

SHH
PTCH1
SUFU
CTNNB1
KCTD11
REN
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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