Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

doi:10.1016/S1470-2045(13)70110-4

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Article

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

The Lancet. Oncology - 1 May 2013

Castelo-Branco Pedro, Choufani Sanaa, Mack Stephen, Gallagher Denis, Zhang Cindy, Lipman Tatiana, Zhukova Nataliya, Walker Erin J, Martin Dianna, Merino Diana, Wasserman Jonathan D, Elizabeth Cynthia, Alon Noa, Zhang Libo, Hovestadt Volker, Kool Marcel, Jones David T W, Zadeh Gelareh, Croul Sidney, Hawkins Cynthia, Hitzler Johann, Wang Jean C Y, Baruchel Sylvain, Dirks Peter B, Malkin David, Pfister Stefan, Taylor Michael D, Weksberg Rosanna, Tabori Uri

Abstract excerpt

BACKGROUND: Identification of robust biomarkers of malignancy and methods to establish disease progression is a major goal in paediatric neuro-oncology. We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours. METHODS: For the discovery cohort, we used samples obtained from patients with paediatric brain tumours and individuals...

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PMID: 23598174
DOI: 10.1016/S1470-2045(13)70110-4

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TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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