Article

Spatial transcriptomics reveals mechanism of autoimmunity driven by internalized autoantibodies

2026-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Autoantibody internalization has been implicated in autoimmune disease pathogenesis, yet its mechanisms, and generality across different diseases, cell types, and affected tissues remain poorly defined. Using bulk RNA sequencing, we identified reproducible, autoantibody-specific transcriptomic signatures consistent with autoantigen dysfunction in muscle biopsies from patients with anti-Mi2 derma...

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Literature Corpus work: b61af064-e6f7-5a69-a15e-20f68b82b177
DOI: 10.64898/2026.02.14.26346329

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