Article

IgG autoantibodies in bullous pemphigoid directly induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes

2024-10-11

Abstract excerpt

<h4> Abstract </h4> While autoantibodies in bullous pemphigoid (BP) are known to activate the innate immune response, their direct effect on keratinocytes, and the contribution of BP-IgG autoantibody-dependent keratinocyte responses to BP pathology is largely unknown. Herein, we performed multiplex immunoassays and bulk RNA-seq on primary keratinocytes treated with IgG from BP patients or controls. We identified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80742966-1eca-5794-83dc-0a09e17ac4b3
DOI: 10.1101/2024.10.07.616103

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IgG autoantibodies in bullous pemphigoid directly induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytesDOI 10.1101/2024.10.07.616103Read

Single cell transcriptome profiling reveals pathogenesis of Bullous PemphigoidSemantic proximity Read

Single cell transcriptome profiling reveals pathogenesis of bullous pemphigoidSemantic proximity Read

A clinically actionable stratification of bullous pemphigoid using a disease activity score reveals a targetable inflammatory endotype.Semantic proximity Read

Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases.Semantic proximity Read

The impact of lesional inflammatory cellular infiltrate on the phenotype of bullous pemphigoid.Semantic proximity Read

Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity.Semantic proximity Read

Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive diseaseSemantic proximity Read

Multi-Omics Molecular Profiling Enables Rapid Diagnosis of Erythrodermic Skin DiseasesSemantic proximity Read

The role of antibody class and target on subepidermal blistering disease phenotype and management.Semantic proximity Read

Bullous pemphigoid: etiology, pathogenesis, and inducing factors: facts and controversies.Semantic proximity Read

Severe epidermolysis bullosa/Kindler syndrome-like phenotype of an autoinflammatory syndrome in a child.Semantic proximity Read

Recent advances in the genetics and innate immune cells of bullous pemphigoidSemantic proximity Read