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Article

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis

4 Jun 2024

Abstract excerpt

Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older adults with no effective therapy available. In contrast to other inflammatory myopathies such as subacute, immune-mediated necrotizing myopathy (IMNM), IBM follows a chronic disease course with both inflammatory and degenerative features of pathology. Moreover, causal factors and molecular drivers of IBM progression are...

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PMID: 38834884
DOI: 10.1038/s43587-024-00645-9

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