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Article

Dynamics of macrophage polarization support Salmonella persistence in a whole living organism.

eLife - 15 Jan 2024

Leiba Jade, Sipka Tamara, Begon-Pescia Christina, Bernardello Matteo, Tairi Sofiane, Bossi Lionello, Gonzalez Anne-Alicia, Mialhe Xavier, Gualda Emilio J, Loza-Alvarez Pablo, Blanc-Potard Anne, Lutfalla Georges, Nguyen-Chi Mai E

Abstract excerpt

Numerous intracellular bacterial pathogens interfere with macrophage function, including macrophage polarization, to establish a niche and persist. However, the spatiotemporal dynamics of macrophage polarization during infection within host remain to be investigated. Here, we implement a model of persistent Salmonella Typhimurium infection in zebrafish, which allows visualization of polarized macrophages and...

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Identifiers

PMID: 38224094
DOI: 10.7554/eLife.89828
PMCID: PMC10830131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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