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A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity

2025-07-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, providing durable and even curative responses. However, most patients do not respond and current biomarkers (eg, programmed death ligand (PD-L1), mismatch repair deficiency (dMMR)/high microsatellite instability (MSI) and tumor mutational burden) lack predictive accuracy. Ex vivo profiling of patient-d...

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Literature Corpus work
b605fb9d-5252-5852-9c6b-4192f6be804f
DOI
10.1101/2025.07.18.663728
Open publication

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A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneityDOI 10.1101/2025.07.18.663728
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