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The application of organoids in treatment decision-making for digestive system cancers: progress and challenges

25 Aug 2025

Abstract excerpt

Digestive system cancers-including gastric, liver, colorectal, esophageal, and pancreatic malignancies-remain leading causes of cancer death, with treatment resistance posing major challenges in advanced disease. Patient-derived cancer organoids (PDCOs), 3D mini-tumors grown from patient biopsies, have revolutionized personalized oncology by faithfully replicating tumor biology and enabling predictive drug...

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PMID: 40855314
DOI: 10.1186/s12943-025-02429-0

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