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Article

Novel approaches to 3D cancer heterospheroid culture and assay development for immunotherapy screening

14 May 2025

Abstract excerpt

Advanced 3D heterospheroids, composed of cancer, fibroblast, and immune cells, serve as more physiologically relevant models for anticancer drug screening and immunotherapy research compared to traditional 2D cultures. This study aimed to optimize the culturing, dissociation, and analysis of heterospheroids, addressing limitations that restrict their broader use in immunotherapy research. Our study revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40379236
DOI: 10.1016/j.yexcr.2025.114604

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