Energy metabolism and cytochrome oxidase activity: linking metabolism to gene expression1

Abstract excerpt

Modification of mitochondrial content demands the synthesis of hundreds of proteins encoded by nuclear and mitochondrial genomes. The responsibility for coordination of this process falls to nuclear-encoded master regulators of transcription. DNA-binding proteins and coactivators integrate information from energy-sensing pathways and hormones to alter mitochondrial gene expression. In mammals, the signaling cascad...

Topics

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• Adipokines, Inflammation, and Metabolic Diseases
• Adipose Tissue and Metabolism
• Cancer, Hypoxia, and Metabolism
• Diet and metabolism studies
• Endoplasmic Reticulum Stress and Disease
• Metabolism, Diabetes, and Cancer
• Mitochondrial Function and Pathology
• Peroxisome Proliferator-Activated Receptors

Identifiers and source

Literature Corpus work

b5f7e49a-09f2-566e-a719-feaaf5e761d6

DOI

10.1139/cjz-2013-0267