Oxidative and nitrosative stress in β-cell apoptosis: their contribution to β-cell lossin type 1 diabetes mellitus

Abstract excerpt

The loss of beta-cell mass consequential to the activation of pro-apoptotic signalling events is increasingly recognised as a causal and committed stage in the development of autoimmune, type 1, diabetes mellitus (DM). While the mechanisms responsible for targeted beta-cell loss are multifaceted and difficult to define at a prediabetic stage, there is a need, from a therapeutic perspective, to understand the...

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