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The function and dysfunction of memory CD 8+ T cells in tumor immunity

17 Apr 2018

Abstract excerpt

ABSTRACT The generation and maintenance of CD8+ T cell memory is crucial to long‐term host survival, yet the basic tenets of CD8+ T cell immunity are still being established. Recent work has led to the discovery of tissue‐resident memory cells and refined our understanding of the transcriptional and epigenetic basis of CD8+ T cell differentiation and dysregulation. In parallel, the unprecedented clinical success...

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PMID: 29664561
DOI: 10.1111/imr.12657

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