Article
Akt signaling is critical for memory CD8+ T-cell development and tumor immune surveillance.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017
Rogel Anne, Willoughby Jane E, Buchan Sarah L, Leonard Henry J, Thirdborough Stephen M, Al-Shamkhani Aymen
Abstract excerpt
Memory CD8+ T cells confer long-term immunity against tumors, and anticancer vaccines therefore should maximize their generation. Multiple memory CD8+ T-cell subsets with distinct functional and homing characteristics exist, but the signaling pathways that regulate their development are ill defined. Here we examined the role of the serine/threonine kinase Akt in the generation of protective immunity by CD8+ T...
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