Article

Mono-ADP-ribosylation-driven immunosuppression and cross-resistance to therapy through cancer cell intrinsic and extrinsic mechanisms

2026-06-03

Abstract excerpt

<h4>SUMMARY</h4> Mono-ADP-ribosylation (MARylation) is emerging as an important regulator of anti-cancer immunity and immunosuppressive tumor microenvironment (TME). Our previous studies showed that PARP11, one of several enzymes that facilitate MARylation, regulates the activities of intratumoral cytotoxic T lymphocytes (CTLs) and regulatory T cells (Tregs). Here, we demonstrate that stimuli such as adenosine, e...

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Literature Corpus work: aa620941-5ac2-5951-ae70-2d612d16b991
DOI: 10.64898/2026.06.01.729331

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