Article

Elastic Fibers in the Pathogenesis of Cystic Fibrosis: Mechanisms, Consequences, and Therapeutic Implications

2026-08-11

Abstract excerpt

Cystic fibrosis (CF) is a multisystem autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, affecting approximately 100,000 individuals worldwide. While the primary pathology of CF has historically been framed around airway mucus obstruction, chronic infection, and neutrophilic inflammation, emerging evidence points to profound remodeling of the ext...

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Literature Corpus work: 4ae45ec9-708b-509c-b913-73284b3aebbc
DOI: 10.20944/preprints202608.0669.v1

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