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An <i>in vitro</i> model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

2022-02-04

Abstract excerpt

Extracellular matrix (ECM) is a dynamic network of proteins, proteoglycans and glycosaminoglycans, providing structure to the tissue and biochemical and biomechanical instructions to the resident cells. In fibrosis, the composition and the organization of the ECM are altered, and these changes influence cellular behaviour. Biochemical (i. e. protein composition) and biomechanical changes in ECM take place simultan...

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Literature Corpus work
1dfeda5d-0477-5a53-87bf-623f2d29703b
DOI
10.1101/2022.02.02.478812
Open publication

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An <i>in vitro</i> model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing compositionDOI 10.1101/2022.02.02.478812
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