Article

The TRX assay for triplet repeat expansions

2024-12-20

Abstract excerpt

Expansion mutations of triplet repeat sequences cause numerous inherited neurological diseases. In some diseases, affected individuals display somatic expansions in affected tissues which have been linked to accelerated disease onset and progression. There is currently considerable interest in developing therapies to slow somatic repeat expansions to delay or block disease onset. In vitro assays are particularly...

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Literature Corpus work: b58fbd4a-e8c1-5cda-a58f-8be3e68048ef
DOI: 10.1101/2024.12.18.629104

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