Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid Molecular Screen of Spinocerebellar Ataxia Types 1, 2, and 3 by Triplet-Primed PCR and Melting Curve Analysis.

The Journal of molecular diagnostics : JMD - 1 May 2021

Lian Mulias, Zhao Mingjue, Phang Gui-Ping, Soong Yun-Ting, Yoon Chui-Sheun, Lee Caroline G, Law Hai-Yang, Chong Samuel S

Abstract excerpt

The autosomal dominantly inherited spinocerebellar ataxias (SCAs) can be caused by dynamic mutations of short tandem repeats within various genes. Because of the significant clinical overlap among the various SCA types, molecular screening of multiple genetic loci by fluorescent PCR and capillary electrophoresis is necessary to identify the causative repeat expansion. We describe a simple, rapid, and inexpensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxin-1
Share to Ataxin-3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Machado-Joseph Disease

Share to Repressor Proteins

Share to Spinocerebellar Ataxias

Share to Transition Temperature

Share to Trinucleotide Repeat Expansion

Source

Identifiers

PMID: 33618058
DOI: 10.1016/j.jmoldx.2021.01.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid Molecular Screen of Spinocerebellar Ataxia Types 1, 2, and 3 by Triplet-Primed PCR and Melting Curve Analysis.PMID 33618058Read ↗

Improved high sensitivity screen for Huntington disease using a one-step triplet-primed PCR and melting curve assay.Semantic proximity Read ↗

Simple procedure for automatic detection of unstable alleles in the myotonic dystrophy and Huntington's disease loci.Semantic proximity Read ↗

Diagnosis of Spinocerebellar Ataxias Caused by Trinucleotide Repeat Expansions.Semantic proximity Read ↗

Diagnosis of five spinocerebellar ataxia disorders by multiplex amplification and capillary electrophoresis.Semantic proximity Read ↗

Single-Tube Screen for Rapid Detection of Repeat Expansions in Seven Common Spinocerebellar Ataxias.Semantic proximity Read ↗

Triplet-Primed PCR Assays for Accurate Screening of FMR1 CGG Repeat Expansion and Genotype Verification.Semantic proximity Read ↗

Triplet repeat primed PCR simplifies testing for Huntington disease.Semantic proximity Read ↗

Defining the performance parameters of a rapid screening tool for myotonic dystrophy type 1 based on triplet-primed PCR and melt curve analysis.Semantic proximity Read ↗

High Throughput Screening for Expanded CTG repeats in Myotonic Dystrophy Type 1 Using Melt Curve AnalysisSemantic proximity Read ↗

Optimized testing strategy for the diagnosis of GAA-FGF14 ataxia/spinocerebellar ataxia 27BSemantic proximity Read ↗

A repeat-primed PCR assay for pentanucleotide repeat alleles in spinocerebellar ataxia type 37.Semantic proximity Read ↗

Caution regarding the interpretation of homoallelism in polyglutamine multiplex assays: a recommendation for confirmatory testing of homozygous alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.