Article

RLIM enhances BMP signalling mediated fetal lung development in mice

2018-12-28

Abstract excerpt

RLIM, also called RNF12, is an X-linked E3 ubiquitin ligase. It is a pleotropic protein acting as a negative regulator of LIM-homeodomain transcription factors and of SMAD7, an antagonist of the BMP and TGFβ pathways. Mutations in RLIM are associated with variable congenital malformations in human. The molecular mechanism causing these malformations is still poorly understood. In this study, we used a conventiona...

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Literature Corpus work: b5853054-e458-52df-bbbc-e806a6f5511f
DOI: 10.1101/507921

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