Article

Gut Microbiome-Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal Cells

2025-03-13

Abstract excerpt

Host circadian signaling, feeding, and the gut microbiome are tightly interconnected. Changes in the gut microbial community can affect the expression of core clock genes, but the specific metabolites and molecular mechanisms that mediate this relationship remain largely unknown. Here, we sought to identify gut microbial metabolites that impact circadian signaling. Through a phenotypic screen of a focused library...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cc8e46a-a034-500d-9400-2f8f5e2d823f
DOI: 10.1101/2025.03.10.642513

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gut Microbiome-Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal CellsDOI 10.1101/2025.03.10.642513Read

Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host CrosstalkSemantic proximity Read

Host-Microbiota Interaction and Intestinal Epithelial Functions under Circadian Control: Implications in Colitis and Metabolic Disorders.Semantic proximity Read

The intestinal circadian clock drives microbial rhythmicity to maintain gastrointestinal homeostasisSemantic proximity Read

The Oscillating Gut Microbiome and Its Effects on Host Circadian BiologySemantic proximity Read

Maintain host health with time-restricted eating and phytochemicals: A review based on gut microbiome and circadian rhythmSemantic proximity Read

Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythmsSemantic proximity Read

The intestinal clock drives the microbiome to maintain gastrointestinal homeostasisSemantic proximity Read

Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese miceSemantic proximity Read

The relationship between host circadian rhythms and intestinal microbiota: A new cue to improve health by tea polyphenolsSemantic proximity Read

Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase ActivitySemantic proximity Read

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene CompositionSemantic proximity Read

Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.Semantic proximity Read