Article

Sirtuin 3 with rs11607019 regulates gene expression in 293 cells

2025-12-05

Abstract excerpt

<h4>Background</h4> SIRT3 is a NAD+ dependent deacetylase located in mitochondria and plays a critical role in various biological processes such as aging and cancer. Recent GWAS analyses have identified an intronic SNP, rs11607019, that significantly influences platelet function. <h4>Methods</h4> To investigate the genome-wide transcriptional effects of this variant, we performed site-directed mutagenesis experi...

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Literature Corpus work: b5457eb2-7e07-5c4a-982b-8cb76c48ee80
DOI: 10.64898/2025.12.03.692027

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