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Article

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.

Neuron - 22 Feb 2017

Cao Mian, Wu Yumei, Ashrafi Ghazaleh, McCartney Amber J, Wheeler Heather, Bushong Eric A, Boassa Daniela, Ellisman Mark H, Ryan Timothy A, De Camilli Pietro

Abstract excerpt

Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of PI(4,5)P2, a reaction needed for the shedding of endocytic factors from their membranes. While the role of SJ1's 5-phosphatase module in this process is well recognized, the contribution of its Sac phosphatase domain, whose preferred substrate is PI4P, remains unclear. Recently a...

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Identifiers

PMID: 28231468
DOI: 10.1016/j.neuron.2017.01.019
PMCID: PMC5340420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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