Article

Enhanced mucosal mitochondrial function corrects dysbiosis and OXPHOS metabolism in IBD

2024-03-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mitochondrial (Mito) dysfunction in IBD reduces mucosal O2 consumption and increases O2 delivery to the microbiome. Increased enteric O2 promotes blooms of facultative anaerobes (eg. Proteobacteria ) and restricts obligate anaerobes (eg. Firmicutes ). Dysbiotic metabolites negatively affect host metabolism and immunity. Our novel compound (AuPhos) upregulates intestinal ep...

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Literature Corpus work: e3ec0040-6dc4-5d1d-8518-fbd62f35c876
DOI: 10.1101/2024.03.14.584471

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