Article

Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis

2020-05-02

Abstract excerpt

Blood-based biomarkers can be informative of brain disorders where protein aggregation play a major role. The proteome of plasma and circulating protein aggregates (CPA) reflect the inflammatory and metabolic state of the organism and can be predictive of system-level and/or organ-specific pathologies. CPA are enriched with heavy chain neurofilaments (NfH), key axonal constituents involved in brain aggregates form...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 509c8432-7334-527f-981a-9744f31dc1a4
DOI: 10.1101/2020.04.30.070979

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosisDOI 10.1101/2020.04.30.070979Read

Analysis of Circulating Protein Aggregates Reveals Pathological Hallmarks of Amyotrophic Lateral SclerosisSemantic proximity Read

The Need for Biomarkers in the ALS–FTD Spectrum: A Clinical Point of View on the Role of ProteomicsSemantic proximity Read

Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral SclerosisSemantic proximity Read

Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applicationsSemantic proximity Read

Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosisSemantic proximity Read

Muscle proteins in plasma associate to distinguished phenotypes in amyotrophic lateral sclerosisSemantic proximity Read

Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosisSemantic proximity Read

Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosisSemantic proximity Read

Proteomic profiling of CSF reveals stage-specific changes in Amyotrophic lateral sclerosis patientsSemantic proximity Read

Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia withC9orf72hexanucleotide repeat expansionSemantic proximity Read

Small peptide fingerprint (peptidomics) of Amyotrophic Lateral Sclerosis in CSFSemantic proximity Read

Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral SclerosisSemantic proximity Read