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Article

Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation.

ACS chemical neuroscience - 6 Nov 2024

Pérez de la Lastra Aranda Carmen, Tosat-Bitrián Carlota, Porras Gracia, Dafinca Ruxandra, Muñoz-Torrero Diego, Talbot Kevin, Martín-Requero Ángeles, Martínez Ana, Palomo Valle

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that currently lacks effective therapy. Given the heterogeneity of clinical and molecular profiles of ALS patients, personalized diagnostics and pathological characterization represent a powerful strategy to optimize patient stratification, thereby enabling personalized treatment. Immortalized lymphocytes from sporadic and genetic ALS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39401249
DOI: 10.1021/acschemneuro.4c00328

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