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On the enigmatic null effect of global methylation perturbation

2024-07-05

Abstract excerpt

Despite the established role of DNA methylation in transcriptional silencing, most of the genes remain unchanged upon its global erasing from the genome, while expression of other genes is actually raised. Since its discovery a few decades ago, this unsolved enigma has hampered true understanding of DNA methylation role. By applying an updated mathematical model to the results of the original studies, we showed th...

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Literature Corpus work
b53a055c-c25f-5254-a656-ede73a831eea
DOI
10.1101/2024.07.03.601377
Open publication

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On the enigmatic null effect of global methylation perturbationDOI 10.1101/2024.07.03.601377
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