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Article

Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data.

Nature biotechnology - 1 Apr 2022

Sun Duanchen, Guan Xiangnan, Moran Amy E, Wu Ling-Yun, Qian David Z, Schedin Pepper, Dai Mu-Shui, Danilov Alexey V, Alumkal Joshi J, Adey Andrew C, Spellman Paul T, Xia Zheng

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages within the context of heterogeneous tissues. However, current single-cell data cannot directly link cell clusters with specific phenotypes. Here we present Scissor, a method that identifies cell subpopulations from single-cell data that are associated with a given phenotype. Scissor integrates phenotype-associated bulk expression...

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Identifiers

PMID: 34764492
DOI: 10.1038/s41587-021-01091-3
PMCID: PMC9010342

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CTLA4
PDCD1
TCF7
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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