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Article

LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.

JCI insight - 16 Jan 2020

Choudhary Mayur, Ismail Ebraheim N, Yao Pei-Li, Tayyari Faryan, Radu Roxana A, Nusinowitz Steven, Boulton Michael E, Apte Rajendra S, Ruberti Jeffrey W, Handa James T, Tontonoz Peter, Malek Goldis

Abstract excerpt

Effective treatments and animal models for the most prevalent neurodegenerative form of blindness in elderly people, called age-related macular degeneration (AMD), are lacking. Genome-wide association studies have identified lipid metabolism and inflammation as AMD-associated pathogenic pathways. Given liver X receptors (LXRs), encoded by the nuclear receptor subfamily 1 group H members 2 and 3 (NR1H3 and NR1H2),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31829999
DOI: 10.1172/jci.insight.131928
PMCID: PMC7030875

Genes

RPE
NR1H2
NR1H3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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