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Article

Ferroptosis in ocular diseases: mechanisms, crosstalk with other cell death pathways, and therapeutic prospects

8 Jul 2025

Abstract excerpt

Background: , triggers iron-dependent lipid peroxidation and ferroptosis. These include disruptions in iron metabolism, oxidative stress imbalances, altered intracellular signaling, and changes to the local microenvironment. Such aberrant ferritin deposits not only compromise the structure and function of ocular cells but also accelerate disease progression. Ferroptosis, a newly recognized form of cell death...

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PMID: 40697914
DOI: 10.3389/fmed.2025.1608975

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