Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NLRP3 Inflammasome and Pathobiology in AMD

14 Jan 2015

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of lipofuscin in the RPE. End-stage disease is characterized by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammasome and immune disorders
Share to Ocular Diseases and Behçet’s Syndrome
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26237026
DOI: 10.3390/jcm4010172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NLRP3 Inflammasome and Pathobiology in AMDPMID 26237026Read ↗

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasomeSemantic proximity Read ↗

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degenerationSemantic proximity Read ↗

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesSemantic proximity Read ↗

Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eyeSemantic proximity Read ↗

Autophagy in age-related macular degenerationSemantic proximity Read ↗

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectivesSemantic proximity Read ↗

Age-Related Macular Degeneration: Cellular and Molecular Signaling MechanismsSemantic proximity Read ↗

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging ProcessSemantic proximity Read ↗

Mechanism of Inflammation in Age-Related Macular DegenerationSemantic proximity Read ↗

Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formationSemantic proximity Read ↗

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationSemantic proximity Read ↗

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.