Article

Oligodendrocyte generation and maturation in the hippocampus may be a target of fluoxetine for delaying cognitive dysfunction during early Alzheimer’s disease

2020-02-26

Abstract excerpt

<title>Abstract</title> Background In the central nervous system, the myelin sheath and the cells that form it—oligodendrocytes—are associated with cognitive function. Oligodendrocyte abnormalities is an important early pathogenic factor of Alzheimer’s disease (AD). However, it is unclear how the hippocampal oligodendrocytes change during early AD and whether early hippocampal oligodendrocyte pathology in AD c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4be8fc1-ea93-5d71-803d-e2eafd47c933
DOI: 10.21203/rs.2.24601/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oligodendrocyte generation and maturation in the hippocampus may be a target of fluoxetine for delaying cognitive dysfunction during early Alzheimer’s diseaseDOI 10.21203/rs.2.24601/v1Read

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's diseaseSemantic proximity Read

Oligodendroglia generate vascular mural cells and neurons in the adult mouse brainSemantic proximity Read

Accelerated dystrophy and decay of oligodendrocyte precursor cells in the APP/PS1 model of Alzheimer’s-like pathologySemantic proximity Read

A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.Semantic proximity Read

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and DiseaseSemantic proximity Read

Accelerated Dystrophy and Decay of Oligodendrocyte Precursor Cells in the APP/PS1 Model of Alzheimer’s-Like PathologySemantic proximity Read

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal ActivitySemantic proximity Read

AAV-mediated neuronal expression of FOXG1 restores oligodendrocyte maturation, myelination, and hippocampal structure in mouse models of FOXG1 syndromeSemantic proximity Read

Fus depleted oligodendrocytes reduce neuronal damage and attenuate AD progression in the App NL-G-F mouseSemantic proximity Read

Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous systemSemantic proximity Read

Molecular markers characterization determining cell fate specification in an adult neurogenesis model of Alzheimer’s diseaseSemantic proximity Read

Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1).Semantic proximity Read