Article

Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production

2024-08-26

Abstract excerpt

The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin system is well understood, other key regulatory factors have remained elusive. Here, we replicated a prior association between a non-coding variant in WNT2B and an increased risk of primary aldosteronism, a...

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Literature Corpus work: b4b4ee8a-2a2b-528b-82c6-c5630ad32942
DOI: 10.1101/2024.08.23.609423

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