Article
Sexually dimorphic interzonal crosstalk reshapes the adrenal cortex in response to pathophysiological challenges
2025-09-10
Abstract excerpt
<h4>Structured Abstract</h4> <h4>Background</h4> Primary aldosteronism is the most common form of secondary arterial hypertension, due to autonomous aldosterone production from the adrenal cortex. Genome wide association studies discovered genetic risk loci associated with the disease, which may affect adrenal cortex renewal, differentiation and lineage conversion. Genetic susceptibility may be modulated by envi...
Topics
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- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hormonal Regulation and Hypertension
- Renal and related cancers
- Reproductive Biology and Fertility
- Sexual Differentiation and Disorders
Identifiers and source
- Literature Corpus work
- 56d5fd8b-6f26-5692-9426-75fa583e24f7
- DOI
- 10.1101/2025.09.05.674435
