Article
Activating mutations in CTNNB1 in aldosterone producing adenomas.
Scientific reports - 27 Jan 2016
Åkerström Tobias, Maharjan Rajani, Sven Willenberg Holger, Cupisti Kenko, Ip Julian, Moser Ana, Stålberg Peter, Robinson Bruce, Alexander Iwen K, Dralle Henning, Walz Martin K, Lehnert Hendrik, Sidhu Stan, Gomez-Sanchez Celso, Hellman Per, Björklund Peyman
Abstract excerpt
Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5-10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically correctable form of the disease. The WNT signaling pathway is activated in APAs. In other tumors, a frequent cause of aberrant WNT signaling is mutation in the CTNNB1...
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