Article

Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation

2018-01-17

Abstract excerpt

<h4>SUMMARY</h4> Copy number gain of the PHGDH gene that encodes the first enzyme of the serine biosynthesis pathway is found in some human cancers, including a subset of melanomas. In order to study the effect of increased PHGDH expression in tissues in vivo , we generated mice harboring a PHGDH tetO allele that allows tissue-specific, doxycycline-inducible PHGDH expression. Tissues and cells derived from P...

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Literature Corpus work: b4953822-44cd-56af-8531-3bc930a4124c
DOI: 10.1101/249250

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