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Article

L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.

Journal of dermatological science - 1 Sept 2011

Bachelor Michael A, Lu Yan, Owens David M

Abstract excerpt

BACKGROUND: L-3-Phosphoserine phosphatase (PSPH) is a highly conserved and widely expressed member of the haloacid dehalogenase superfamily and the rate-limiting enzyme in l-serine biosynthesis. We previously found Psph expression to be uniquely upregulated in a α6β4 integrin transgenic mouse model that is predisposed to epidermal hyperproliferation and squamous cell carcinoma (SCC) formation implicating a role...

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Identifiers

PMID: 21726982
DOI: 10.1016/j.jdermsci.2011.06.001
PMCID: PMC3152677

Genes

PSPH

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