Article

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

2024-05-26

Abstract excerpt

Dyschromatosis universalis hereditaria (DUH) is a rare genetic dermatosis characterized by widespread hyperpigmentation and depigmentation. In our previous study, we identified SH3 domain-containing protein 1 (SASH1) mutations associated with the DUH phenotype in Chinese families and predict SASH1/ THBS1/ TGF-β1 signaling to mediate melanin production and melanocyte transport. We detected SASH1/ THBS1/ TGF-β1 pa...

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Literature Corpus work: bbd68e70-398c-50c3-94ea-a7f8f5af6cb6
DOI: 10.1101/2024.05.22.595382

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