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Time-course Transcriptomics Reveals the Impact of <i>Treponema pallidum</i> on Microvascular Endothelial Cell Function and Phenotype

2025-05-06

Abstract excerpt

<h4>Summary</h4> Syphilis, caused by Treponema pallidum subsp. pallidum, is an urgent global public health threat. Syphilis vaccine development has been impeded by limited understanding of the molecular mechanisms that enable T. pallidum to establish and maintain infection. The vascular endothelium is critical for T. pallidum attachment, dissemination, and host immune response initiation; however, the molecul...

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Literature Corpus work
594ae1b1-c120-53ef-b88d-070488710ffd
DOI
10.1101/2025.05.04.651946
Open publication

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