Article

Spatial mapping of Ethiopian cutaneous leishmaniasis lesions reveals distinct tissue level immune programs

2026-02-05

Abstract excerpt

Ethiopian cutaneous leishmaniasis (CL) shows remarkably heterogeneous clinical presentations, but the underlying immunopathological mechanisms driving this heterogeneity in disease presentation remains poorly understood. To characterise the local immune response in Ethiopian CL, we performed spatial transcriptomics on paired lesional and non-lesional skin punch biopsies from five Ethiopian CL patients. We used ref...

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Literature Corpus work: 9dac8a27-6a05-5e58-9287-572a8bc107dc
DOI: 10.64898/2026.02.04.26345554

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