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Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in <i>ARID1B</i> -related neurodevelopmental disorders

2021-04-02

Abstract excerpt

The BAF complex modulates chromatin accessibility. Specific BAF configurations have functional consequences, and subunit switches are essential for cell differentiation. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause a neurodevelopmental disorder spectrum, including Coffin-Siris syndrome, which is characterized by neurological and crani...

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Literature Corpus work
f860768c-0189-516b-b010-0d437451c20c
DOI
10.1101/2021.04.02.438227
Open publication

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Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in <i>ARID1B</i> -related neurodevelopmental disordersDOI 10.1101/2021.04.02.438227
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