Back to search

Article

A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts

2023-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases. A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, incident dementia, and mortality. Here, we tested for associations between DunedinPACE and structural MRI phenotypes in three datasets spanning midlife to advanced age...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b453b6bb-03ff-501e-a220-1c7ec3390342
DOI
10.1101/2023.09.06.23295140
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohortsDOI 10.1101/2023.09.06.23295140
Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring CohortSemantic proximity
An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortalitySemantic proximity
Quantification of the pace of biological aging in humans through a blood test: The DunedinPoAm DNA methylation algorithmSemantic proximity
Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and DementiaSemantic proximity
Are sex differences in cognitive impairment reflected in epigenetic age acceleration metrics?Semantic proximity
DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity
DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity
How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated agingSemantic proximity
An epigenetic predictor of death captures multi-modal measures of brain healthSemantic proximity
Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)Semantic proximity
GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.Semantic proximity
Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity
Select a neighboring publication to make it the new centre.