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Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort

1 Oct 2024

Abstract excerpt

INTRODUCTION: The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS: = 62, SD = 9, range = 25-101 y). We measured cognitive decline across two decades of neuropsychological-testing follow-up. We measured pace of aging using the DunedinPACE epigenetic clock. Analysis tested if participants with faster DunedinPACE values experienced more rapid cognitive decline...

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PMID: 39583644
DOI: 10.1002/dad2.70038

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