Article
GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.
The journals of gerontology. Series A, Biological sciences and medical sciences - 30 Apr 2021
McCrory Cathal, Fiorito Giovanni, Hernandez Belinda, Polidoro Silvia, O'Halloran Aisling M, Hever Ann, Ni Cheallaigh Cliona, Lu Ake T, Horvath Steve, Vineis Paolo, Kenny Rose Anne
Abstract excerpt
The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. Epigenetic clocks measure changes in DNA methylation levels at specific CpG sites that are highly correlated with calendar age. The discrepancy resulting from the regression of DNA methylation age on calendar age is...
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