Article

Senescence Associated Secretory Proteins Induced in Lung Adenocarcinoma by Extended Treatment with Dexamethasone Enhance Migration and Activation of Lymphocytes

2022-07-26

Abstract excerpt

There is a need to improve response rates of immunotherapies in lung adenocarcinoma (AC). Extended (7–14 day) treatment of high glucocorticoid receptor (GR) expressing lung AC cells with dexamethasone (Dex) induces an irreversible senescence phenotype through chronic induction of p27. As the senescence associated secretory phenotype (SASP) may have either tumor supporting or antitumor immunomodulatory effects, it...

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Literature Corpus work: b43ebd21-a491-5834-8459-ff8e27d10327
DOI: 10.21203/rs.3.rs-1874725/v1

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