Article
Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2024
Ostrowska Kamila, Niewinski Patryk, Piotrowski Igor, Ostapowicz Julia, Koczot Sabina, Suchorska Wiktoria Maria, Golusiński Paweł, Masternak Michal Mateusz, Golusiński Wojciech
Abstract excerpt
BACKGROUND: Cellular senescence is a state characterized by cell-cycle arrest and apoptotic resistance. Senescence in cancer may be induced by oncogenes or therapy. While cellular senescence might play an important role in protection against cancer development, elevated and uncontrolled senescent cells accumulation may promote carcinogenesis by secreting a collection of pro-inflammatory factors, collectively...
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