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A lmod1a mutation causes megacystis microcolon intestinal hypoperistalsis in a CRISPR/Cas9-modified zebrafish model

2024-08-29

Abstract excerpt

<title>Abstract</title> <p>Purpose Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is defined as a congenital visceral myopathy with genetic mutations. However, the etiology and pathophysiology are not fully understood. We aimed to generate a gene <italic>leiomodin-1a</italic> (<italic>lmod1a</italic>) modification technique to establish a zebrafish model of MMIHS. Methods We targeted <italic>...

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Literature Corpus work
b07943b0-85b2-55cd-b401-c47048cf19fa
DOI
10.21203/rs.3.rs-4847189/v1
Open publication

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A lmod1a mutation causes megacystis microcolon intestinal hypoperistalsis in a CRISPR/Cas9-modified zebrafish modelDOI 10.21203/rs.3.rs-4847189/v1
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