Article
Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine.
Developmental cell - 1 May 2005
Wallace Kenneth N, Dolan Amy C, Seiler Christoph, Smith Erin M, Yusuff Shamila, Chaille-Arnold Linda, Judson Ben, Sierk Rachel, Yengo Christopher, Sweeney H Lee, Pack Michael
Abstract excerpt
Zebrafish meltdown (mlt) mutants develop cystic expansion of the posterior intestine as a result of stromal invasion of nontransformed epithelial cells. Positional cloning identified zebrafish smooth muscle myosin heavy chain (myh11) as the responsible gene. The mlt mutation constitutively activates the Myh11 ATPase, which disrupts smooth muscle cells surrounding the posterior intestine. Adjacent epithelial cells...
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